Young woman, routine Pap smear.
What are these cells? What caused these changes? Dx?
![Slide 1](/sites/g/files/zaskib621/files/styles/1920_x_variable/public/2022-02/PIC1%20web.jpg?itok=zJKddJPv)
![Slide 2](/sites/g/files/zaskib621/files/styles/1920_x_variable/public/2022-02/PIC2%20web.jpg?itok=_uQpTiug)
Answer:
koilocytes: mature squamous cells with HPV cytopathic changes(≥1 hyperchromatic enlarged nuclei, surrounded by perinuclear halo, thick cytoplasmic rim). Low grade squamous intraepithelial lesion (LSIL).